Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype.

This association and its clinical implications could be validated in the Athero-Express Biobank cohort, with significantly lower plaque SPTBN1 protein expression in CVD event-free patient than in patients with an CVD even during follow-up, albeit that this effect was borderline significant (P = 0.06) (Fig. 6 D).

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Plaque content of CD105 + angiogenic ECs was seen to correlate with plaque size and, at borderline significance, with lipid core size and intraplaque hemorrhage.

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Validation in the BIKE cohort showed a highly significant 40% lower sptbn1 mRNA expression in symptomatic than asymptomatic patients (Fig. 6 E).

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