Despite similar magnitude with our observed associations, the inverse association (HR, 0.88; 95% CI, 0.72-1.07) between lignan intake and T2D incidence did not achieve significance at the EPIC-InterAct case-cohort study. 11 This inconsistency between the current and existing studies underscores the complexity of establishing a clear dose-response association across a wide range of lignan intakes, and may also be partially explained by differences in study design and statistical power on the ability to detect modest associations.
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