Copper Isotope Evidence of Oxidative Stress-Induced Hepatic Breakdown and the Transition to Hepatocellular Carcinoma.

The correlation of δ 65 Cu with the fibrosis score ( Figure 1 B) is highly significant ( P < .001 from controls to the F0-F1-F2, and P < .0001 from F0-F1-F2 to F3-F4). 18 iii. δ 65 Cu is significantly lower for the NAFLD (bariatric) group than for the control group ( P = .0004). 20 Seric δ 65 Cu values of obese patients fall within the same range as other HCC-negative patients but are higher than those of HCC-positive patients and are in good agreement with those obtained by Hastuti et al. 35 Figure 2 shows the results of the fit of the cumulated frequencies of the control, HCC-negative, and HCC-positive populations by a mixture of 2 and 3 normal cdf’ s.

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