Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes.

However, a highly significant reduction ( p < 0.001; ~ 5-log 10 ) was observed when GQA was combined with imipenem, indicating that GQA was more effective than clavulanic acid but similar in its activity to tazobactam (Fig. 2 B).

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