Evaluation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Analysis of Glucosylceramide and Galactosylceramide Isoforms in Cerebrospinal Fluid of Parkinson's Disease Patients.

15 − 18 , 30 However, those that studied larger cohorts and stratified individuals by mutation type found higher concentrations in the PD-GBA group and an increasing trend with mutation severity. 15 , 17 A reduction in GalCer, and potentially an upregulated ratio, was also found in patients with idiopathic normal pressure hydrocephalus, a parkinsonian disorder. 30 These studies suggest a link among lipid metabolism dysregulation, ALP dysfunction, and neurological damage, even in the absence of GBA variants, which is also consistent with our findings in the iPD group.

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