Identification and experimental validation of programmed cell death- and mitochondria-associated biomarkers in osteoporosis and immune microenvironment.

Furthermore, correlation analysis revealed a highly significant positive correlation between CD56dim natural killer cells and ACAA2 (cor = 0.291, p = 0.009), whereas a highly significant negative correlation was observed between central memory CD4 + T cells and DAP3 (cor = −0.381, p = 0.0004; Figure 5C ; Supplementary Table S3 ). 3.6 DAP3 , BIK , and ACAA2 were regulated by multiple factors Using the NetworkAnalyst database, 24, 15, and 27 TFs were predicted to regulate the expression of DAP3, BIK, and ACAA2.

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