LIM-domain-only 4 (LMO4) enhances CD8<sup>+</sup> T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling.

LMO4 overexpression boosts IL-21-mediated STAT3 signaling to orchestrate a memory-promoting gene regulatory network Among the pathways influenced by both LMO4 and c-Myb manipulation, we also observed a highly significant enrichment of the Reactome pathway R-MMU-1280215, which relates to cytokine signaling ( P < 0.001) and includes several molecules involved in STAT signaling (Fig. 4e , Supplementary Table 5 ).

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