Further, adding MethylSig-UM to a validated clinico-genomic prognostic model, PriMeUM, which accounts for tumor size, patient sex, and age as well as prognostic CNAs, MethylSig-UM remained prognostic while PriMeUM was borderline significant in the validation cohort ( Table 3 B).
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Genome-Wide Methylation Patterns in Primary Uveal Melanoma: Development of MethylSig-UM, an Epigenomic Prognostic Signature to Improve Patient Stratification.
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