Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study.

With adjustment for baseline UPCR in Model 4, the hazard ratio for High/High 2-year pattern was still significantly different from the Low/Low pattern (HR, 1.61; 95% CI, 1.07-2.42) though the overall type 3 P value testing for differences between all levels of the variable was marginally nonsignificant at P = 0.09.

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MMP-2 has also been shown to have an increasing trend with increasing CKD stages; 34 however, we did not find effect modification by eGFR, suggesting the interaction between MMP-2 and proteinuria cannot fully be explained by CKD stage.

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