Causes of Death and Mortality Trends in Individuals with Thalassemia in the United States, 1999-2020.

5 However, there is an increasing trend of prevalence in the other regions, namely North America and Northern Europe attributed to migrations. 6 In the United States, there was 7.5% increase in the prevalence of thalassemia in the last fifty years. 7 Patients with thalassemia have varying presentation ranging from asymptomatic or mild anemia among patients with thalassemia trait to severe anemia requiring lifelong blood transfusion among thalassemia major patients.

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The AAMR of thalassemia-related death showed a decreasing trend from 0.50 (95% CI, 0.41–0.58) in 1999 to 0.48 (95% CI, 0.41–0.55) in 2020 with the AAPC of −1.42 (95% CI, −2.42, −0.42).

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