Networks of the overlapping proximity proteomes between two baits with highly significant SFARI gene enrichment (Syngap1 and Anks1b) and three similarity-clustered AIS baits (Ank3, Scn2a, and Scn8a) revealed shared pathways that emphasized glutamate receptor and voltage-gated channel activities, respectively, and common modules that were involved in actin organization in both networks (Fig. 1E,F ).
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Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.
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