Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma.

Intriguingly, the transcript levels of most candidate genes showed a moderate to strong correlation with the H3K27ac ChIP-seq signals of the associated SEs, with marginal significance in HMCLs and primary patient samples (r > 0.4, p < 0.1, Supplementary Fig. 4e ).

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