Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites.

Compared to peaks containing L-CTCF-BSs, P-CTCF-BSs exhibited a higher mutation rate of 1.34 and 1.25 times per CTCF-BS for LNCaP and MCF7 respectively ( Supplementary Table S4 ), and the elevated rate is highly significant ( P -value < 1 × 10 −8 ) as determined by a permutation test (Materials and methods) (Figure 2A , B ).

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