Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.

2 D compares the levels of GDNF RNA specifically in cholinergic neurons of the dorsal striatum of WT and LRRK2 G2019S mice (from snRNAseq analysis); these neurons showed a highly significant decrease in GDNF transcription, as would be predicted from earlier findings ( 15 ).

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