Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles.

AMs of both age groups showed high preferential uptake for (-)NPs; however, the aged AM group demonstrated a highly significant ( p < 0.001) decrease in uptake of (-)NPs ( Fig. 4 B ) .

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While both DC types appeared to have a slight trend toward (+)NP preference in %NP + , there was significantly higher quantity of (-)NP uptake in the young population of CD103 + DCs (Fig. 4 H).

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