Cluster effect for SNP-SNP interaction pairs for predicting complex traits.

For example, the TIR S1K for the C1–C2 pair with the highly significant interaction (p-pair = 4.5 × 10 –18 ) were 96.5% vs. 90.9% based on 1000 simulation runs by using 1pRule vs. 3pRule, respectively, under a sample size of 20,000.

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The mean correlations between rs4802755-rs4473378 and significant null pairs involved with the hub SNP of rs4802755 demonstrated a decreasing trend (r = 0.88 to 0.64) as MAF of null SNPs went up from 5 to 50%.

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