Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes.

6 , 7 Consequently, tendinopathies impair daily activities and diminish quality of life, imposing substantial socioeconomic burden exciding EUR 180 billion in the USA and EU, with an increasing trend. 6 For many years, the prevailing paradigm in the field of tendinopathy has been that inflammation is the primary aspect to be tackled, leading to research focused on developing drugs to resolve inflammation. 8 , 9 Hence, the most commonly utilized therapeutics in the clinic for the management of tendinopathy include corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs).

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