Alterations in the gut microbiome and metabolism profiles reveal the possible molecular mechanism of renal injury induced by hyperuricemia in a mouse model of renal insufficiency.

Heatmap analysis of differentially abundant metabolites involved in pathways revealed significant reductions in 4-hydroxyphenylpyruvic acid, 1-methylhistamine, homogentisic acid, and formiminoglutamic acid when the UNx + HPD group was compared with the sham group; conversely, an increasing trend was observed in L-phenylalanine, urocanic acid, L-aspartic acid, normetanephrine, 3,4-dihydroxymandelate, vanillymandelic, and dopamine5,6-dihydroxyindol ( Figure 4D ).

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