Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: preclinical evidence and phase I clinical trial.

By monitoring T cells in the PB of patients, we found a decreasing trend in the T-cell proportion, while the CD8 + T-cell proportion exhibited an increasing trend.

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The flow cytometry results showed an increasing trend in CD103-positive DC subsets (Supplementary Fig.

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