Could Less Be More? Accounting for Fractional-Dose Regimens and Different Number of Vaccine Doses When Measuring the Impact of the RTS,S/AS01E Malaria Vaccine.

Although superiority of fractional- vs full-dose regimens was not demonstrated and the complementary impact analyses were post hoc, we showed an overall trend of higher vaccine impact for fractional- vs full-dose regimens of RTS,S, supporting flexibility around timing and dosing in the vaccination schedule.

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