A decreasing trend was also observed in the viral RNA level of turbinates and tracheas when mice were inoculated with rGD0601/PB2-I714S, particularly in turbinates at 1 dpi ( Figure 6 (B)).
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The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly.
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