Establishing the Safety and Efficacy of Bedaquiline-Containing Regimen for the Treatment of Drug-Resistant Tuberculosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

These include the following from clinicaltrials.gov registries: • NCT05381194 : BPaL[M] regimen for the treatment of MDR/RR-TB • NCT05040126 : modified BPaL regimen for managing pre-XDR TB and MDR (TI/NR) TB in India (mBPaL) • NCT06058299 : Phase 2 trial assessing TBAJ876 or BDQ, with pretomanid and linezolid in adults with drug-sensitive pulmonary tuberculosis These pursuits toward establishing the risks and benefits of these combination drugs are a positive trend that will advance the use of BDQ and help fight against DR-TB for decades to come. 4.1.

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