Tirzepatide Improved Health-Related Quality of Life Compared with Insulin Lispro in Basal Insulin-Treated Adults with Type 2 Diabetes and Inadequate Glycaemic Control: A Randomised Controlled Phase 3b Trial (SURPASS-6).

Association Between Weight Reduction and PROs Although statistical tests were not conducted, results of these additional exploratory post hoc analyses showed that there was a numerical trend towards improved SF-36v2 Physical and Mental Component Summary scores in participants treated with tirzepatide achieving greater percentage reductions in weight, with participants achieving ≥ 15% weight reduction reporting the greatest improvements in component summary scores (after adjustment for baseline PRO scores) (Fig. 5 a).

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