In the granulocyte compartment, both CD.I and UC.I patients displayed an increased proportion of basophils (adjusted P = .028 and < 0.001, respectively), and UC.I an increased proportion of neutrophils (adjusted P = .023), with a borderline significance for in CD.I (adjusted P = .051).
The most significant pathway cluster of CD.nI was an upregulation of “neutrophil degranulation” but also the downregulated “major pathway of rRNA processing in the nucleolus and cytosol.” Additional highly significant clusters included, for example, downregulated “tRNA processing” as well as upregulated “platelet activation, signaling, and aggregation” and “Leishmania infection.” The most significant pathway cluster of UC.nI was the upregulated “neutrophil degranulation” but also the upregulated “antigen process