Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis.

Conversely, BRD4 showed an increasing trend immediately after release from DTB for 10 h ( Figure 1D , lane #5), followed by a dramatic decrease at the 12-h time point when PLK1 reached its peak ( Figure 1D , lane #6).

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