Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8<sup>+</sup> cytotoxic T cell recruitment to pancreatic tumours.

Front Immunol · 2024 · PMC11334161 · PMID 39165364

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borderline significantno p-value reported

Furthermore, borderline significant increases in expression are observed for Cxcl9 in TAMs ( Figure 3I ) and Cxcl10 in CAFs ( Figure 3J ) upon IGF blockade.

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Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8&lt;sup&gt;+&lt;/sup&gt; cytotoxic T cell recruitment to pancreatic tumours.

The sentences

Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8<sup>+</sup> cytotoxic T cell recruitment to pancreatic tumours.