Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies.

The linear mixed model M5-(described in the Methods “Statistical analyses”)-based post-hoc comparisons of 31 P MRS parameters in the hippocampus, the motor cortex, and the premotor cortex between MMD patients and control family members revealed significantly ( p < 0.05) decreased levels of PCr (phosphocreatine)/ATP and PCr/P i (inorganic phosphate) and increased (trending toward significance; p = 0.088) levels of P i /ATP in all selected brain areas of MMD patients (Table 1 and Fig. 6 ).

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