Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance.

Notably, TR-d3 intensity showed a decreasing trend from ventral brain to dorsal brain ( Figure 1(h) ), and subregional quantification showed that TR-d3 penetrated less into the dorsal, lateral, ventral, and hippocampus of PND mice than CON mice ( Figure 1(i) and (j) ).

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