Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca²⁺ dynamics in prediabetic beta cells.

The correlation of insulin values with [Ca 2+ ] i dynamics coordination revealed a positive trend in WD-fed female mice during the entire diet intervention period (Fig. 4 i–k) while WD-fed males only retained this adaptive mechanism for 2 months (Fig. 4 i).

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