highly significantp = 0.001
4C becoming highly significant (both increasing vs increasing-decreasing p = 0.001; both increasing vs other p = 0.013; both decreasing vs increasing-decreasing p < 0.001; both decreasing vs other p < 0.001; LME post-hoc tests, Tukey correction), as well as the difference between increasing-decreasing and other pairs becoming significant ( p = 0.040).