Increased mRNA expression for serotonin receptor 1B (HTR1B) is associated with thrombosis in BCR::ABL1-negative myeloproliferative neoplasms.

HTRB1 gene expression analysis in relation to thrombotic events Due to the large variation in fold change values across MPN subtypes, we analysed the clinical data of MPN patients and observed highly significant increased levels of HTR1B expression in patients who either had at least one episode of major thrombosis (ischemic stroke, deep vein thrombosis with or without pulmonary embolism, splanchnic vein thrombosis) at the time of diagnosis or on the recent history, or showed signs of impaired microcircula

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