highly significantp < 0.001
4 A) revealed a highly significant effect ( F 1,45 = 15.2, p < 0.001) of repeated measures (i.e., a statistically significant increase in grimacing on day 1; 18–36 h post–surgery) but no ZT group × repeated measures interaction ( F 3,45 = 0.05, p = 0.99).