highly significantp -value = 0.00082
In the Kaplan-Meier curve of the external dataset, we observed a highly significant association between the high- and low-risk groups and survival time ( p -value = 0.00082), providing strong evidence for the suitability of our model in prognostic prediction. 3.3 Multivariate cox regression analysis and TF-target gene network construction To explore other additional factors affecting CRC, a total of 317 samples, including phenotypic data, were subjected to Cox single-factor regression analysis for age, sex, pathological stage, lymphatic invasion, and risk score.