Notably, the metabolite involved in secondary bile acid metabolism and derived from the GM - TUDCA, showed a decreasing trend in patients with IGT, and similar changes were observed in numerous metabolites involved in amino acid metabolism, including tryptophyl-methionine, tryptophyl-valine, and Trp-P-1, the latter being a carcinogenic heterocyclic amine.
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The gut microbiota intervenes in glucose tolerance and inflammation by regulating the biosynthesis of taurodeoxycholic acid and carnosine.
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