For instance, how are parH3:H4tet transferred to the replicating chromatin? Are old and newly synthesized histones assembled into nucleosomes at the leading and lagging DNA strands differently? How are histone markers, such as methylation and acetylation, copied from the parental histones to newly synthesized histones following DNA replication to maintain epigenetic information? These fundamental questions, related to parental histone transfer, are highly significant as they are related to human disease pathology and stem differentiation [ 18 , 23 , 24 , 25 ].
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