Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage.

This was a highly significant difference ( p < 0.0001) compared to the age-matched hSOD1-WT mice ( Figure 6 B).

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The slight delay in the age of treatment initiation may be significant, but perhaps more importantly, diapocynin has much less CNS permeability than apocynin [ 61 ].

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