borderline significantP = 1.63 × 10 −4
Among them, brain natriuretic peptide (BNP) was the only biomarker with a borderline significant association with IMI (HR per doubling of BNP level (95% confidence interval (95% CI)) = 1.33 (1.15, 1.55), P = 1.63 × 10 −4 , FDR = 0.11 in the discovery sample and 1.40 (1.00, 1.94), P = 0.049 in the validation sample; Extended Data Fig. 2 ).