Safety and efficacy of L-Glutamine in reducing the frequency of acute complications among patients with sickle cell disease: A randomized controlled study.

Several studies prove the effect of l-glutamine on reducing the frequency of VOCs; a randomized controlled trial recruited 81 SCD patients aged from 9 to 58 years, who were randomized 1:1 to glutamine 0.3 g/kg orally twice daily or placebo for 48 weeks showed that l-glutamine therapy reduced the frequency of hospitalization and indicated a positive trend towards reducing the frequency of painful crises [ 10 ], also results of a phase 3 trial showed that treatment with l-glutamine led to a statistically significant reduction in the frequency of pain crises and rates of hospitalization [ 7 ], Elenga and his colleagues reported that SCD patients, whom nearly half of them receiving HU simultaneously (47%), demonstrated a clinically significant reduction in the median frequency of VOCs at 24-, 48- and 72-weeks following L-glutamine therapy compared to the preceding year [ 32 ].

also in 10,439 other papers

There was a decreasing trend in the number, severity, and hospitalization of VOC and a significantly lower cumulative number of VOCs and hospitalizations in the glutamine group than in SOC (p = 0.008, p < 0.001 respectively).

also in 44,411 other papers