investigated the association between HR defects and genomic patterns of LOH in two cohorts of epithelial ovarian tumors, finding a highly significant correlation between a HRD score defined as the number of LOH regions of intermediate size (> 15 Mb, but shorter than the length of the whole chromosome) and HR deficiency, measured by BRCA1/2 and RAD51C mutations ( 18 ).
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Current HRD assays in ovarian cancer: differences, pitfalls, limitations, and novel approaches.
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