Prenatal cell-free DNA testing of women with pregnancy-associated cancer: a retrospective cross-sectional study.

For case NIPT-67 (cervical cancer), we found a borderline significant CNV gain of chromosome band 3q26 which did not meet the Maastricht criteria for ‘malignancy-suspicious’, but is a known hallmark of squamous cervical carcinomas ( Supplemental Table S2 ). 16 Time between NIPT and cancer diagnosis and symptoms of disease The mean time between the NIPT and the diagnosis of pregnancy-associated cancer was statistically significantly shorter for the group with a malignancy suspicious-NIPT result when compared with the group with a non-suspicious NIPT result, respectively 49.9 days (± SD 31.8) and 100.7 days (± SD 74.9), p = 0.001 ( Fig. 3 ).

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