Small molecule <i>α</i>-methylene-<i>γ</i>-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype <i>via</i> interference DNA binding activity of NF-<i>κ</i>B.

α-M-γ-B disrupts the DNA binding of NF-κB via direct interaction with NF-κB p65 Our previous study with network pharmacology predicted that the RELA gene (responsible for encoding the NF- κ B p65) emerged as a highly significant target implicated in both the occurrence and progression of RA 32 .

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