Optimization of Lipid-Based Nanoparticles Formulation Loaded with Biological Product Using A Novel Design Vortex Tube Reactor via Flow Chemistry.

The experimental results, summarized in Table 3 , indicate substantial variations in z-average, ranging from 153.1 to 323.1 nm for LNPs under different combinations of X 1 , X 2 , and X 3 The cubic model from partial least square (PLS) regression analysis, as presented in Table 4 , reveals a highly significant relationship between the independent variables and Y 1 ( p -value = 0.0069), with an impressively high R 2 (0.9988).

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