Prognostic relevance of tumor-infiltrating CD4<sup>+</sup> cells and total metabolic tumor volume-based risk stratification in diffuse large B-cell lymphoma.

Comparable values for TMTV, baseline IPI components, IPI category, and COO were observed between groups with high and low intratumoral CD4 + cell burden, except for a lower prevalence of Eastern Cooperative Oncology Group performance status (ECOG PS) score ≥2 with marginal significance (14.5% vs. 27.4%, P =0.065) in those with low intratumoral CD4 + cells.

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