Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii.

Indeed, there does not appear to be an obvious trend when considering only the basicity of the tail group either as the dimethyl amino tail, with intermediate basicity, led to the most active compound, 36 .

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The zwitterionic nature of this S-MGB, and thus lower logP, may be significant in the observed potency towards Acanthamoeba castellanii , as a comparison of S-MGB-241, 36 , with its methyl ester analogue, S-MGB-238, 30 , reveals the latter to have no measurable activity against A. castellanii .

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