304 Data from NNIS from January 1992 through June 2004 showed that the median rate of CRBSI in ICUs of all types ranged from 1.8 to 5.2 per 1000 catheter days, 305 whereas more recent survey in 2010 showed the mean incidence up to 1.76 per 1000 catheter days, suggesting a decreasing trend. 306 Data from extended prevalence of infection in intensive care study (EPIC 2) showed an overall point prevalence of 4.7 per 1000 catheter days. 307 In the EPIC III study, 1239 (15.2%) patients had CRBSI with a hospital mortality of 38.1%. 308 A prospective observational study by Lorente et al. showed incidence of CC as 6.04 % and of CRBSI to be 2.79 per 1000 catheter days. 309 Other studies have shown global incidence of CC to be 1.4-20 % while that of CRBSI to be 2.4–12.5 per 1000 catheter days. 310 – 313 Majority of these studies have shown CVCs as the commonest cause for CRBSIs.
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