Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression.

While amplitude, area and decay time of spontaneous currents were similar in the two groups, PCDH19- neurons were characterized by a significant higher frequency of mIPSCs and a decreasing trend in the frequency of mEPSC, suggesting an unbalance in favor of inhibitory synaptic inputs (Fig. 3g, h ).

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