Examining the evolving landscape of liver cancer burden in the United States from 1990 to 2019.

Data from the Surveillance, Epidemiology, and End Results (SEER) program further support our results, showing an increasing trend in the age-adjusted incidence rates of liver and intrahepatic bile duct cancer in the US [ 20 ].

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For instance, while a decreasing trend in both ASIR and age-standardized death rates of primary liver cancer worldwide was previously found [ 7 ], our study found an opposing trend in the US, especially among cases related to alcohol consumption, which may stem from various factors.

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