Time-restricted eating with or without a low-carbohydrate diet improved myocardial status and thyroid function in individuals with metabolic syndrome: secondary analysis of a randomized clinical trial.

As the most sensitive and significant serum biomarker of thyroid function, TSH decreased only in the combination group according to the ITT analysis and showed a decreasing trend but was insignificant in the combination group according to the PP analysis, which is consistent with the findings of several trials that failed to detect any significant changes in TSH after LCD or TRE intervention [ 26 – 28 ].

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