Dynamics and implications of anti-drug antibodies against adalimumab using ultra-sensitive and highly drug-tolerant assays.

Moreover, the IgG class was the primary contributor to ADA against adalimumab and the apparent affinity exhibited an increasing trend over time, indicating a T-cell dependent mechanism for ADA elicitation by adalimumab.

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The apparent K D values showed a decreasing trend over time in a subgroup of 9 patients ( Figure 4E ), suggesting an enhancement in affinity with longer treatment duration.

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