A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy.

In response to these challenges of conventional prodrug strategy, carrier-free prodrug nanoassembly, integrating prodrug strategy and biomedical nanotechnology into one system [24] , has emerged as a notable trend to facilitate more efficient delivery of anticancer drugs in recent decades [18 , [25] , [26] , [27] , [28] , [29] .

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